Lysine, L-Arginine &
Herpes Simplex Virus


The human Herpes Simplex Virus (HSV) is a recurrent viral infection that is caused by Herpes virus hominis (HVH), a widespread infectious agent.

The human herpes viruses are multipotential, and inclu+de HSV types 1 and 2, human cytomegalovirus, Varicella-Zoster virus, and the Epstein-Barr Virus.

These viruses are transmitted by respiratory and oral secretions and commonly produce fever blisters, cold sores, flu-like symptoms, headache, swollen glands, and may also infect the urethra causing burning sensations during urination. There is currently no cure for HSV, but there are measures that can be taken to reduce manifestations.

Increased levels of lysine over arginine suppress viral replication and inhibit cytopathogenicity of herpes simplex virus (HSV).

This interaction between the amino acids lysine and arginine can be mitigated by taking L-lysine supplements about 2 hours separately from L-arginine.


Many L-Arginine products seen on the market contain both Lysine and L-Arginine. This is an example of incorrect formulating, as Lysine is a direct antagonist of L-Arginine and cannot be used together in any L-Arginine product.

Combining Lysine with L-Arginine is one of the most prominent formulating mistakes in nutrition supplements. Lysine should never be combined with L-arginine, but is often seen in L-arginine products with the purpose of mitigating the herpes reaction. This combining technique is a result of bad science, as it negates the benefits of L-arginine.

Lysine directly competes with L-Arginine, and formulas/products that contain both Lysine and L-Arginine do not work, due to the chemical antagonism.

The combination of Lysine and L-Arginine are examples of dietary disproportions of amino acids, which are counterproductive and can alter serum levels of amino acids.

The Lysine/Arginine antagonism is an example of this alteration. A plethora of definitive clinical studies have proven that L-Arginine and Lysine are antagonistic in humans, such as the Johns Hopkins University published trial showing the direct competition of Lysine and L-Arginine.


L-Arginine can be specifically formulated and bioengineered to reduce the effects of herpes simplex as stimulated by lack of Lysine. This was accomplished by the renowned Arginine researcher, Dr. Ann de Wees Allen in 1983, when Dr. Allen discovered the process for downregulating the L-Arginine-Lysine activation of the Herpes Simplex Virus.

In order to safely use an L-Arginine formula or product, persons that have latent or active Herpes Simplex Virus, will need to use a specific form of L-Arginine that contains a Blind Amino Acid Rider.


Herpes Simplex Virus (HSV) is greatly aggravated by lack of sleep and stress. Eight hours of sleep per night is required to reduce activation of HSV.
During human sleep cycles, immune function is activated, which affects the herpes simplex virus, as well as all viruses.

Additionally, if sleep cycles and nutrient intake is not balanced, HSV will become prominent with manifestations such as cold sores and lethargy.


Lysine has been used effectively as an agent for reduction of occurrence, severity and healing time for recurrent HSV infection. Supplementation with free-form L-lysine has shown to be beneficial in controlling herpes symptoms.

The amount of Lysine required to control herpes varies from case to case, but a typical dose to maintain remission (as stated in most trials) is 500-1000 milligrams (mg), and for active herpes, 1000 mg (1 gram) to 6000 mg (6 grams) taken daily.

Clinical trials suggested that persons with the Herpes Simplex Virus take 1000 mg of oral L-lysine in capsule form, a few times per day (1-3), taken 2 hours apart from the L-arginine (due to antagonism).

In terms of controlling HSV outbreaks, UCLA School of Medicine (Dr. Griffith, Dr. Kagan, Dr. Norins) found that there is a 96% success rate in patients taking 1500 mg of supplemental L-lysine daily.

Lysine supplements in capsule form are the most efficacious and can be found in most health food stores. When selecting a Lysine supplement, Lysine should be the only ingredient listed on the label, as the addition of any other amino acid or ingredient can negate its benefit. Tablets are to be avoided.

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