Reduced arginine availability results in
reduced NO synthesis. Arginine availability for NO synthesis
is regulated by de novo arginine synthesis, arginase
activity, and cellular arginine transport. Arginase is generated
by excessive NO levels, and is to be avoided under any circumstance
in an L-Arginine or NO formula.
Excess (excessive) NO creates a
toxic environment in the human body, and low levels of NO
(reduced endogenous NO) are ineffective, so NO
highs and lows are to be avoided. In terms of fertility
in males, NO reduces or inhibits sperm motility, while NOS
inhibitors, which inhibit the formation of NO, prevent the
reduction of sperm motility, indicating a role for the L-arginine-NO
pathway in the modulation of sperm motility and motility
Sperm motility is negatively affective by
both reduced and excessive endogenous Nitric Oxide (NO).
The mechanism of reduced fertility in males, related
to NO, is a function of the effect of reactive oxygen species
(ROS) on sperm membranes, which depresses sperm function.
Stress also exacerbates reduced motility of sperm. Excessive
NO levels in seminal plasma are associated with poor
Excessive generation of NO can be toxic
and reduce sperm motility. Further, excessive NO contributes
to the formation of a highly toxic anion of peroxidation,
called peroxynitrite. The unpaired electrons of NO and O2
define peroxynitrite as a 1-or-2-electron oxidant and nitrating
agent, and not a typical free radical.
Numerous clinical studies have demonstrated
that peroxidation decreases sperm count and motility, and
loss of the capacity of the spermatozoon to undergo the
acrosome reaction and fertilization.
Therefore, NO formulas and products must
be produced under strict GMP manufacturing guidelines utilizing
long-term proven methodologies in L-arginine biochemistry.
The manufacture of NO formulas and products should not
be attempted by persons unfamiliar with L-Arginine NO toxic
byproducts and the Blind Amino Acid personality
of amino acids, such as Arginine. Click